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| miRIDIAN® microRNA Research Products |
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Human, Mouse, and Rat microRNA reagents designed for use in microRNA functional characterization studies. |
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New! Designs now updated to Sanger miRBase 10.1.
MicroRNAs (miRNAs) are a growing class of small, noncoding RNAs (22-24nt) that regulate gene expression by targeting mRNAs for translational repression, degradation, or both. These molecules are emerging as important modulators in cellular pathways such as growth and proliferation, apoptosis, and developmental timing.
For a comprehensive review of miRNA biogenesis and function, read our Tech Review: "microRNA Discovery, Biogenesis and Research Areas."
To date, thousands of miRNAs have been identified in organisms from viruses to primates through cloning and sequencing, or computational prediction based on strong conservation of miRNA sequence motifs. miRNA data are managed and annotated by the miRBase Sequences Database, hosted by the Sanger Institute as a publicly accessible repository.
To advance research on the function and mechanisms of these molecules, Dharmacon offers the miRIDIAN microRNA research products.
Our recommended reading list covers many seminal miRNA publications and frequently-cited articles from journals and texts.
NOW AVAILABLE: Novel, next-generation microRNA inhibitors for long-lived potent inhibition
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microRNA Pathway. Click to enlarge. |
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| To find your miRNA: |
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miRIDIAN microRNA Mimics:
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| • Synthetic miRNA Mimics designed to enter miRNA pathway and act as mature miRNA species |
| • Supplement native miRNA activity to further decrease steady-state protein levels and study gain-of-function effects |
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New! miRIDIAN microRNA Hairpin Inhibitors:
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| • Synthetic miRNA Inhibitors designed to specifically target and irreversibly bind endogenous miRNAs |
| • Suppress native miRNA activity to increase protein levels and study loss-of-function effects |
| • Novel, proprietary design confers greater potency and longevity of inhibition |
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miRIDIAN microRNA Mimic and Hairpin Inhibitor Negative Controls:
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| • Mimic and Inhibitor molecules based on C. elegans miRNAs with no known homologs in human, mouse, or rat |
| • For use as non-targeting negative controls in Inhibitor and Mimic experimentation |
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miRIDIAN microRNA Mimic and Hairpin Inhibitor Libraries:
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| • Collections designed for every human, mouse, and rat miRNA in the current Sanger miRBase Registry |
| • For phenotypic screening and identification of miRNAs within specific cellular pathways or processes |
| • Now updated to Sanger miRBase Sequence Database version 10.1 |
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