miRIDIAN™ microRNA Inhibitors & Mimics

MicroRNAs (miRNAs) are small endogenous RNA molecules (~21-25 nt) that regulate gene expression by targeting one or more mRNAs for translational repression or cleavage. Several hundred miRNAs have been identified in organisms as diverse as viruses, worms, and primates through cloning or computational prediction. Information on miRNAs is currently managed and annotated by miRBase, which is a publicly available repository hosted by the Sanger Institute (http://microrna.sanger.ac.uk).

To promote research on the biochemistry and biological function of these molecules, Dharmacon offers the miRIDIAN™ microRNA product line. Dharmacon miRIDIAN miRNA Inhibitors and Mimics are designed based on known or predicted miRNA sequences for human, mouse and rat in miRBase.

miRNA inhibitors facilitate loss-of-function studies, while miRNA mimics may be useful for gain-of-function studies.

Additional information on miRNA mimics and inhibitors are available for download:

Dharmacon miRNA Mimics (144K)
Dharmacon miRNA Inhibitors (143K)