siARRAY® siRNA Libraries for Human, Mouse & Rat

Dharmacon has extended its library collection with the addition of the most popular libraries now being available with specificity-enhanced ON-TARGETplus siRNA , reducing off-target effects by up to 90%.

All libraries are also now available in smaller aliquots (0.5 nmol) [more]
Act now - limited time offer on siARRAY libraries

10% off any ON-TARGETplus siRNA libraries*
25% off any standard siARRAY ®siRNA libraries*

Reference promotion code
LIB100106.2
when ordering.

* Excludes Whole Genome and Druggable Genome libraries. Offer valid through 31-Dec-2006.
Using Effective Controls for RNA Interference (RNAi) Experiments

siRNA-mediated RNAi has become an indispensable tool in functional genomics research. Chemically synthesized siRNA reagents that target every gene in human, mouse and rat genome are available for convenient delivery in vitro. How can you ensure that your conclusions are accurate?... [more]
Strategies for Improving siRNA-Mediated Target Knockdown

RNAi experiments typically conclude with the detection of target knockdown via detection of mRNA, protein, or altered phenotypes to determine the extent of target knockdown.  However, these results may reveal less than desirable levels of target knockdown. [more]
DharmaFECT® Transfection Reagents for siRNA Transfection into Embryonic Stem Cells

Stem cells hold the promise of eternal propagation and unlimited differentiation into multiple cell types.  Characterization of adult stem cells for many tissues such as brain, blood, skin, retina and liver has been reported.  The differentiation potential of adult stem cells...[more]
3 Recent Papers on the Significance of siRNA Design

Recently, three articles were published in the journal RNA detailing cutting-edge siRNA research conducted by Dharmacon scientists concerning the importance of siRNA design on target specificity and cell viability. [more]
It's time for a new edition of my biochemistry textbook
Jon Karpilow, PhD

My biochemistry book, a classic 2nd edition of Lehninger from 1978, sits on the top shelf at home and tells me that RNA belongs to three functional groups – messenger RNA (mRNA), ribosomal RNA (rRNA) and transfer RNA (tRNA). In 1978, mRNA was the most abundant of these three, and was known to serve a critical function...[more]
Dharmacon SMARTpool® siRNA Reagents identify regulators of insulin-responsive glucose transport– a critical component in the etiology of type 2 diabetes mellitus.
Ciaran J. Faherty, Ph.D.

Diabetes, a metabolic disorder, is a global health concern that is projected to afflict 366 million people by the year 2030. While diabetes is treatable with exogenous insulin hormone [more]
Survey: DETECTION of RNAi Knockdown Events

Dharmacon wants your feedback regarding detection of RNAi knockdown events. Please take a moment to answer these 6 multiple choice questions concerning your experience with detection.

A FREE Dharmacon T-Shirt will be given to those participants completing the survey. [Take the survey now >]
The First Year in Review

This summer, the RNAi Global Initiative celebrates its first full year as an alliance of not-for-profit institutions involved in biomedical research. The varied research interests of the current member institutions include cancer biology, inflammation, pathway elucidation, target validation, small molecule screens, host-pathogen interactions in infectious diseases and the development of unbiased screens for novel gene targets. [more]
Event
Date
Booth No.
RNAi Europe
9/28-29
3
Neuroscience
10/14-18
2412
Discovery On Target
10/23-27
22
American Society of Cell Biology
12/9-13
625


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