Thermo Scientific Dharmacon pre-defined or custom siRNA libraries in human and mouse are available in any of our three market-leading siRNA technologies for screens with efficient, specific and guaranteed* knockdown
- ON-TARGETplus siRNA - Patented dual-strand modification pattern for unmatched specificity proven to reduce off-target effects up to 90%
- siGENOME siRNA - The most cited siRNA for high-confidence silencing
- Accell siRNA - Uniquely modified for delivery into difficult-to-transfect cells without a transfection reagent
Additional unique screening formats provide flexibility, convenience and higher confidence in screening results.
- Duet siRNA Libraries - Paired siGENOME and ON-TARGETplus siRNA libraries increase overall hit confidence and reduce follow up steps for hit stratification
- Reverse Transfection Format (RTF) siRNA libraries - Unique pre-plated format reduces hands-on time for faster results. Provided as quadruplicate single-use plate sets - just rehydrate and add cells.
Click here to view available quantities and review siRNA Library guidelines for plate type information, recommended storage conditions, and resuspension strategies.
siRNA Formats: Our Guarantee
The siGENOME and ON-TARGETplus SMARTpool siRNA reagent and at least 3 of 4 individual siRNAs will silence target gene expression by at least 75% at the mRNA level when used under optimal delivery conditions (confirmed using a validated control siRNA). Silencing should be monitored at the mRNA level 24 - 48 hours after transfection using 100 nM siRNA.
Note: Most siGENOME and ON-TARGETplus siRNA products are highly functional at 5-20nM working concentration. Accell siRNA products work at a higher concentration (1µM) and are not covered by the abovementioned functional guarantee.