shRNA Research Products

Thermo Scientific now has the largest offering of shRNA technology provided in either plasmid or viral format

SMARTvector 2.0 Lentiviral shRNA Particles

• Stable gene silencing for long-term knockdown studies
• Unique microRNA expression scaffold for efficient processing of the shRNA
• Groundbreaking Dharmacon SMARTvector shRNA design algorithm
• Ready-to-use lentiviral particles allow ease of application
• Provided as high-titer (≥108 TU per mL) purified and concentrated lentiviral particle stocks

Learn more about SMARTvector 2.0 Lentiviral shRNA Particles »

Additional shRNA Research Products are available through the Thermo Scientific Open Biosystems website:

Open Biosystems Genome-Scale shRNA Libraries

Specific and Efficient Gene Knockdown

• Lentiviral shRNAmir—Visually track shRNAmir expression
  • GIPZ—Constitutive
  • TRIPZ—Inducible
• Retroviral shRNAmir—Express with variable promoters
  • pSM2—U6 promoter
  • pSMP—Viral LTR promoter
• Lentiviral shRNA
  • pLKO.1 —U6 promoter

Learn more about Genome-Scale shRNA Libraries »

Open Biosystems Decode RNAi Viral Screening Libraries

Multiplexed RNAI Screens

• Ready-to-use viral pool format
• 10k constructs per pool, 7 pools target the entire human genome
• Lentiviral delivery for RNAi in dividing and non-dividing cell lines
• Cost-effective genome-scale RNAi

Learn more about Multiplexed RNAI Screens »

Open Biosystems RNAintro Kits

shRNAmir Starter Kits for guaranteed knockdown

• RNAintro Transduction Kit: Five shRNAmir contructs, controls and lentiviral packaging system
• RNAintro Transfection Kit: Five shRNAmir contructs, controls and Arrest-In transfection reagent

Learn more about RNAintro Kits »

Open Biosystems shRNA Gene Families and Pathway Sets

Defined by Gene Ontology (GO)

• Available as lentiviral or retroviral shRNA
• Custom sets can be created
• Corresponding cDNAs and ORFs for hit validation or antibodies for detection
  

Learn more about shRNA Gene Families and Pathway Sets »