Dharmacon RNAi Discovery and Therapeutic Services (RDTS) enable RNAi-based target discovery and therapeutic development for a wide range of applications
We offer complete RNAi screening solutions to accelerate drug discovery and therapeutic development by combining advanced RNAi reagents, assay technology, and lab automation. Our services can range from a single screen to multi-component program projects that support critical drug discovery activities such as:
- Target identification
- Target validation
- Drug rescue, repositioning, and patent extension
- Biomarker discovery
- RNAi therapeutic technology development
Our contract research services provide clients with access to unmatched scientific expertise and the most advanced reagents and bioinformatics tools in the field of RNAi. This combination leads to the rapid generation of meaningful results and expert recommendations, which transition screening results into drug target leads. These services are ideal for researchers needing supplemental screening capacity or can be used when internal expertise and infrastructure are not available.
Find out more about our complete range of contract research services in:
The Dharmacon RDTS services portfolio includes high-throughput screening of the most trusted and widely cited pre-designed siRNA libraries in the world. RDTS will develop and validate customized assays for siRNA library screening of:
- Human or mouse whole genome
- Human druggable genome
- Human or mouse gene families
- Custom libraries for unique experimental requirements
MicroRNA expression profiling permits the identification and validation of microRNA function in both the pathology of disease and the profiling of responses to therapeutic intervention. RDTS offers microarray-based microRNA expression analysis to
- Study changes in microRNA levels throughout disease onset and progression
- Identify microRNAs that have potential diagnostic or prognostic value
- Evaluate microRNA expression in response to drug treatment
- Understand microRNA roles in fundamental cellular physiology
Successful development of RNAi therapeutics requires expertise in the design and synthesis of highly functional RNAi reagents, novel formulations and strategies for delivery, and innovations in medicinal chemistry that enhance stability, specificity and biodistribution. Through access to a broad portfolio of IP, the Thermo Scientific life science team offers the most complete services currently available to ensure quality data for RNAi therapeutic programs.
High-Content Analysis Services
Please call (800) 235-9880 or e-mail us at dharmacon.rnai_services@thermofisher.com with any questions about chemical compound screening and profiling. Dharmacon RDTS encompass high-throughput HCA services that include complete data analysis, report generation and data transfer capabilities. These studies range from small profiles to primary screens and extensive follow-up work using the BioImage Redistribution assay technology and Cellomics HCS Reagent Kits.