MicroRNAs (miRNAs) are a growing class of small, noncoding RNAs (17-27 nucleotides) that regulate gene expression by targeting mRNAs for translational repression, degradation, or both. These molecules are emerging as important modulators in cellular pathways such as growth and proliferation, apoptosis, and developmental timing.
To date, thousands of miRNAs have been identified in organisms from viruses to primates through cloning and sequencing, or computational prediction based on strong conservation of miRNA sequence motifs. miRNA data are managed and annotated by the miRBase Sequence Database, Faculty of Life Sciences at the University of Manchester as a publicly accessible repository.
To advance research on the function and mechanisms of these molecules, we offer Thermo Scientific Dharmacon miRIDIAN microRNA research products.
miRIDIAN microRNA Mimics
- Synthetic miRNA Mimics designed to enter miRNA pathway and act as mature miRNA
- Supplement native miRNA activity to further decrease steady-state protein levels and study gain-of-function effects
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miRIDIAN microRNA Hairpin Inhibitors
- Synthetic miRNA Inhibitors designed to specifically target and irreversibly bind endogenous miRNAs
- Suppress native miRNA activity to increase protein levels and study loss-of-function effects
- Novel, proprietary design confers greater potency and longevity of inhibition
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miRIDIAN microRNA Mimic and Hairpin Inhibitor Positive and Negative Controls
- Mimic and Hairpin Inhibitor Positive Controls to evaluate function and determine optimal assay conditions
- Non-targeting Mimic and Hairpin Inhibitor Negative Controls distinguish between specific and background effects
- Dye-labeled Transfection Controls optimize delivery conditions for Mimic and Hairpin Inhibitor experiments
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miRIDIAN microRNA Mimic and Hairpin Inhibitor Libraries
- Collections designed for every human, mouse, and rat miRNA in the Sanger miRBase Registry
- For phenotypic screening and identification of miRNAs within specific cellular pathways or processes
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