Human, mouse, and rat microRNA Mimics are designed for use in microRNA functional characterization studies
Thermo Scientific Dharmacon miRIDIAN microRNA Mimics are double-stranded RNA oligonucleotides, chemically modified with the Dharmacon ON-TARGET modifications and available for all human, mouse, and rat miRNAs in the miRBase Database Sequence 13.0.
Highlights
- Superior performance in comparison to native double-stranded microRNA (Figure 1)
- Effective mimic of endogenous mature miRNA function (Figure 2)
- Preferential programming of RISC with active strand of miRNA and exclusion of passenger strand through proprietary chemical modification patterning
Applications
- Supplement miRNA activity to study gain-of-function effects
- Screen for miRNAs that regulate gene expression and affect cellular pathways
- Elucidate miRNA involvement in normal biological and disease pathways
- Identify and validate miRNA targets